The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes.
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ABSTRACT:
SUBMITTER: Buzsaki G
PROVIDER: S-EPMC4907333 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes.
Buzsáki György G Anastassiou Costas A CA Koch Christof C
Nature reviews. Neuroscience 20120518 6
Neuronal activity in the brain gives rise to transmembrane currents that can be measured in the extracellular medium. Although the major contributor of the extracellular signal is the synaptic transmembrane current, other sources--including Na(+) and Ca(2+) spikes, ionic fluxes through voltage- and ligand-gated channels, and intrinsic membrane oscillations--can substantially shape the extracellular field. High-density recordings of field activity in animals and subdural grid recordings in humans ...[more]
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