Dataset Information
SpectralTDF: transition densities of diffusion processes with time-varying selection parameters, mutation rates and effective population sizes.
Ontology highlight
ABSTRACT: Motivation
In the Wright-Fisher diffusion, the transition density function describes the time evolution of the population-wide frequency of an allele. This function has several practical applications in population genetics and computing it for biologically realistic scenarios with selection and demography is an important problem.Results
We develop an efficient method for finding a spectral representation of the transition density function for a general model where the effective population size, selection coefficients and mutation parameters vary over time in a piecewise constant manner.Availability and implementation
The method, called SpectralTDF, is available at https://sourceforge.net/projects/spectraltdf/Contact
yss@berkeley.eduSupplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Steinrucken M
PROVIDER: S-EPMC4907395 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
SpectralTDF: transition densities of diffusion processes with time-varying selection parameters, mutation rates and effective population sizes.
Bioinformatics (Oxford, England) 20151109 5
<h4>Motivation</h4>In the Wright-Fisher diffusion, the transition density function describes the time evolution of the population-wide frequency of an allele. This function has several practical applications in population genetics and computing it for biologically realistic scenarios with selection and demography is an important problem.<h4>Results</h4>We develop an efficient method for finding a spectral representation of the transition density function for a general model where the effective p ...[more]