Ontology highlight
ABSTRACT:
SUBMITTER: Chellappa K
PROVIDER: S-EPMC4907689 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Chellappa Karthikeyani K Deol Poonamjot P Evans Jane R JR Vuong Linh M LM Chen Gang G Briançon Nadege N Bolotin Eugene E Lytle Christian C Nair Meera G MG Sladek Frances M FM
eLife 20160511
HNF4α has been implicated in colitis and colon cancer in humans but the role of the different HNF4α isoforms expressed from the two different promoters (P1 and P2) active in the colon is not clear. Here, we show that P1-HNF4α is expressed primarily in the differentiated compartment of the mouse colonic crypt and P2-HNF4α in the proliferative compartment. Exon swap mice that express only P1- or only P2-HNF4α have different colonic gene expression profiles, interacting proteins, cellular migration ...[more]