Ontology highlight
ABSTRACT:
SUBMITTER: Menzella F
PROVIDER: S-EPMC4907717 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Menzella Francesco F Lusuardi Mirco M Montanari Gloria G Galeone Carla C Facciolongo Nicola N Zucchi Luigi L
Therapeutics and clinical risk management 20160608
Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal outcome, in a small percentage of patients. Within the different inflammatory cascades involved in asthma, eosinophils play a central role in the pathogenesis and largely influence disease severity. Interleukin-5 (IL-5) is the main cytokine controlling eosinophil activity and proliferation at the site o ...[more]