Ontology highlight
ABSTRACT:
SUBMITTER: Nover AB
PROVIDER: S-EPMC4907770 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nover Adam B AB Jones Brian K BK Yu William T WT Donovan Daniel S DS Podolnick Jeremy D JD Cook James L JL Ateshian Gerard A GA Hung Clark T CT
Journal of biomechanics 20160209 5
Engineering of large articular cartilage tissue constructs remains a challenge as tissue growth is limited by nutrient diffusion. Here, a novel strategy is investigated, generating large constructs through the assembly of individually cultured, interlocking, smaller puzzle-shaped subunits. These constructs can be engineered consistently with more desirable mechanical and biochemical properties than larger constructs (~4-fold greater Young׳s modulus). A failure testing technique was developed to ...[more]