Ontology highlight
ABSTRACT:
SUBMITTER: Dumanski JP
PROVIDER: S-EPMC4908225 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Dumanski Jan P JP Lambert Jean-Charles JC Rasi Chiara C Giedraitis Vilmantas V Davies Hanna H Grenier-Boley Benjamin B Lindgren Cecilia M CM Campion Dominique D Dufouil Carole C Pasquier Florence F Amouyel Philippe P Lannfelt Lars L Ingelsson Martin M Kilander Lena L Lind Lars L Forsberg Lars A LA
American journal of human genetics 20160523 6
Men have a shorter life expectancy compared with women but the underlying factor(s) are not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal neurodegenerative disorder and many germline inherited variants have been found to influence the risk of developing AD. Our previous results show that a fundamentally different genetic variant, i.e., lifetime-acquired loss of chromosome Y (LOY) in blood cells, is associated with all-cause mortality and an increased risk of non-hemat ...[more]