Analysis of differential splicing suggests different modes of short-term splicing regulation.

ABSTRACT:

Motivation

Alternative splicing is an important mechanism in which the regions of pre-mRNAs are differentially joined in order to form different transcript isoforms. Alternative splicing is involved in the regulation of normal physiological functions but also linked to the development of diseases such as cancer. We analyse differential expression and splicing using RNA-sequencing time series in three different settings: overall gene expression levels, absolute transcript expression levels and relative transcript expression levels.

Results

Using estrogen receptor α signaling response as a model system, our Gaussian process-based test identifies genes with differential splicing and/or differentially expressed transcripts. We discover genes with consistent changes in alternativ

SUBMITTER: Topa H 

PROVIDER: S-EPMC4908367 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature