Ontology highlight
ABSTRACT:
SUBMITTER: Ochi T
PROVIDER: S-EPMC4908404 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Ochi Takanori T Feng Yongjia Y Kitamoto Sho S Nagao-Kitamoto Hiroko H Kuffa Peter P Atarashi Koji K Honda Kenya K Teitelbaum Daniel H DH Kamada Nobuhiko N
Scientific reports 20160615
Intestinal resident macrophages (Mϕs) regulate gastrointestinal homeostasis via production of an anti-inflammatory cytokine interleukin (IL)-10. Although a constant replenishment by circulating monocytes is required to maintain the pool of resident Mϕs in the colonic mucosa, the homeostatic regulation of Mϕ in the small intestine (SI) remains unclear. Here, we demonstrate that direct stimulation by dietary amino acids regulates the homeostasis of intestinal Mϕs in the SI. Mice that received tota ...[more]