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In vivo Monitoring of Serotonin by Nanomaterial Functionalized Acupuncture Needle.


ABSTRACT: Acupuncture treatment is amazing but controversial. Up to now, the mechanism of treating diseases by acupuncture and moxibustion is still unclear, especially the occurrence of the molecular events in local acupoints. Herein, we report an extremely stable microsensor by modifying carbon nanotube (CNT) to the tip surface of acupuncture needle and applying this CNT-modified acupuncture needle for real time monitoring of serotonin (5-HT) in vivo. To stabilize CNT modification on the needle tip surface, poly(3,4-ethylenedioxythiophene)(PEDOT) was employed as glue water to stick CNT on the needle. The detection limit of the CNT-modified needle was found to be approximately 50?nM and 78?nM in the PBS and the cell medium, respectively. In addition, the needle showed good selectivity to some inflammatory mediators and some electroactive molecules. For the first time, the CNT-modified needle could be directly probed into rat body for real time monitoring of 5-HT in vivo, showing a great potential for better understanding the mechanism of acupuncture treatment.

SUBMITTER: Li YT 

PROVIDER: S-EPMC4908407 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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In vivo Monitoring of Serotonin by Nanomaterial Functionalized Acupuncture Needle.

Li Yu-Tao YT   Tang Li-Na LN   Ning Yong Y   Shu Qing Q   Liang Feng-Xia FX   Wang Hua H   Zhang Guo-Jun GJ  

Scientific reports 20160615


Acupuncture treatment is amazing but controversial. Up to now, the mechanism of treating diseases by acupuncture and moxibustion is still unclear, especially the occurrence of the molecular events in local acupoints. Herein, we report an extremely stable microsensor by modifying carbon nanotube (CNT) to the tip surface of acupuncture needle and applying this CNT-modified acupuncture needle for real time monitoring of serotonin (5-HT) in vivo. To stabilize CNT modification on the needle tip surfa  ...[more]

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2022-09-22 | GSE206341 | GEO