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Crystal structure of l-leucyl-l-isoleucine 2,2,2-tri-fluoro-ethanol monosolvate.

ABSTRACT: Hydro-phobic dipeptides with either l-Leu or l-Phe constitute a rather heterogeneous group of crystal structures. Some form materials with large water-filled channels, but there is also a pronounced tendency to incorporate organic solvent mol-ecules, which then act as acceptors for one of the three H atoms of the charged N-terminal amino group. l-Leu-l-Ile has uniquely been obtained as two distinct hydrates, but has so far failed to co-crystallize with a simple alcohol. The present structure of C12H24N2O3·CF3CH2OH, which crystallizes with two dipeptide and two solvent mol-ecules in the asymmetric unit, demonstrates that when 2,2,2-tri-fluoro-ethanol is used as a solvent, its high capacity as a hydrogen-bond donor leads to formation of an alcohol solvate.

SUBMITTER: Gorbitz CH

PROVIDER: S-EPMC4908515 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Crystal structure of l-leucyl-l-isoleucine 2,2,2-tri-fluoro-ethanol monosolvate.

Görbitz Carl Henrik CH

Acta crystallographica. Section E, Crystallographic communications 20160405 Pt 5

Hydro-phobic dipeptides with either l-Leu or l-Phe constitute a rather heterogeneous group of crystal structures. Some form materials with large water-filled channels, but there is also a pronounced tendency to incorporate organic solvent mol-ecules, which then act as acceptors for one of the three H atoms of the charged N-terminal amino group. l-Leu-l-Ile has uniquely been obtained as two distinct hydrates, but has so far failed to co-crystallize with a simple alcohol. The present structure of ...[more]

PMID: 27308007

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