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Different N-H?? inter-actions in two indole derivatives.

ABSTRACT: We describe the syntheses and crystal structures of two indole derivatives, namely 6-isopropyl-3-(2-nitro-1-phenyl-eth-yl)-1H-indole, C19H20N2O2, (I), and 2-(4-meth-oxy-phen-yl)-3-(2-nitro-1-phenyl-eth-yl)-1H-indole, C23H20N2O3, (II); the latter crystallizes with two mol-ecules (A and B) with similar conformations (r.m.s. overlay fit = 0.139?Å) in the asymmetric unit. Despite the presence of O atoms as potential acceptors for classical hydrogen bonds, the dominant inter-molecular inter-action in each crystal is an N-H?? bond, which generates chains in (I) and A+A and B+B inversion dimers in (II). A different aromatic ring acts as the acceptor in each case. The packing is consolidated by C-H?? inter-actions in each case but aromatic ?-? stacking inter-actions are absent.

SUBMITTER: Kerr JR

PROVIDER: S-EPMC4908542 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Different N-H⋯π inter-actions in two indole derivatives.

Kerr Jamie R JR Trembleau Laurent L Storey John M D JM Wardell James L JL Harrison William T A WT

Acta crystallographica. Section E, Crystallographic communications 20160415 Pt 5

We describe the syntheses and crystal structures of two indole derivatives, namely 6-isopropyl-3-(2-nitro-1-phenyl-eth-yl)-1H-indole, C19H20N2O2, (I), and 2-(4-meth-oxy-phen-yl)-3-(2-nitro-1-phenyl-eth-yl)-1H-indole, C23H20N2O3, (II); the latter crystallizes with two mol-ecules (A and B) with similar conformations (r.m.s. overlay fit = 0.139 Å) in the asymmetric unit. Despite the presence of O atoms as potential acceptors for classical hydrogen bonds, the dominant inter-molecular inter-action in ...[more]

PMID: 27308022

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