EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1.
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ABSTRACT:
SUBMITTER: Chang YS
PROVIDER: S-EPMC4909124 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1.
Chang Yung-Sheng YS Chen Wei-Yu WY Yin Juan Juan JJ Sheppard-Tillman Heather H Huang Jiaoti J Liu Yen-Nien YN
Cancer research 20150612 15
Dysregulation of the EGFR signaling axis enhances bone metastases in many solid cancers. However, the relevant downstream effector signals in this axis are unclear. miR-1 was recently shown to function as a tumor suppressor in prostate cancer cells, where its expression correlated with reduced metastatic potential. In this study, we demonstrated a role for EGFR translocation in regulating transcription of miR-1-1, which directly targets expression of TWIST1. Consistent with these findings, we ob ...[more]
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