Dataset Information

Structural Changes of Inner and Outer Choroid in Central Serous Chorioretinopathy Determined by Optical Coherence Tomography.

ABSTRACT:

Purpose

To determine the structural changes of the choroid in eyes with central serous chorioretinopathy (CSC) by enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods

A retrospective comparative study was performed at two academic institutions. Forty eyes with CSC, their fellow eyes, and 40 eyes of age-matched controls were studied. Subfoveal cross sectional EDI-OCT images were recorded, and the hypo reflective and hyperreflective areas of the inner and outer choroid in the EDI-OCT images were separately measured. The images were analyzed by a binarization method to determine the sizes of the hyporeflective and hyperreflective areas.

Results

In the inner choroid, the hyperreflective area was significantly larger in the CSC eyes (35,640±10,229 ?m2) than the fellow eyes (22,908±8,522 ?m2) and the control eyes (20,630±8,128 ?m2; P<0.01 vs control for both, Wilcoxon signed-rank test). In the outer choroid, the hyporeflective area was significantly larger in the CSC eyes (446,549±121,214 ?m2) than the control eyes (235,680±97,352 ?m2, P<0.01). The average ratio of the hyporeflective area to the total choroidal area was smaller in the CSC eyes (67.0%) than the fellow eyes (76.5%) and the control eyes (76.7%) in the inner choroid (P<0.01, both). However, the ratio was larger in the CSC eyes (75.2%) and fellow eyes (71.7%) than in the control eyes (64.7%) in the outer choroid (P<0.01, both).

Conclusions

The larger hyperreflective area in the inner choroid is related to the inflammation and edema of the stroma of the choroid in the acute stage of CSC. The larger hyporeflective areas in the outer choroid is due to a dilatation of the vascular lumens of the larger blood vessels. These are the essential characteristics of eyes with CSC regardless of the onset.

SUBMITTER: Sonoda S

PROVIDER: S-EPMC4909210 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Structural Changes of Inner and Outer Choroid in Central Serous Chorioretinopathy Determined by Optical Coherence Tomography.

Sonoda Shozo S Sakamoto Taiji T Kuroiwa Nobuhiro N Arimura Noboru N Kawano Hiroki H Yoshihara Naoya N Yamashita Takehiro T Uchino Eisuke E Kinoshita Takamasa T Mitamura Yoshinori Y

PloS one 20160615 6

<h4>Purpose</h4>To determine the structural changes of the choroid in eyes with central serous chorioretinopathy (CSC) by enhanced depth imaging optical coherence tomography (EDI-OCT).<h4>Methods</h4>A retrospective comparative study was performed at two academic institutions. Forty eyes with CSC, their fellow eyes, and 40 eyes of age-matched controls were studied. Subfoveal cross sectional EDI-OCT images were recorded, and the hypo reflective and hyperreflective areas of the inner and outer cho ...[more]

PMID: 27305042

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Dataset Information

Structural Changes of Inner and Outer Choroid in Central Serous Chorioretinopathy Determined by Optical Coherence Tomography.

Purpose

Methods

Results

Conclusions

Publications

Structural Changes of Inner and Outer Choroid in Central Serous Chorioretinopathy Determined by Optical Coherence Tomography.

Similar Datasets

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