Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants.
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ABSTRACT:
SUBMITTER: Ulaganathan VK
PROVIDER: S-EPMC4909399 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants.
Ulaganathan Vijay K VK Ullrich Axel A
Molecular & cellular oncology 20160224 3
In cancer biology, somatic mutations in the extracellular (ligand binding) and cytosolic (functional/catalytic) domains are pursued with great interest. However, in our recent publication we report that germline mutations in the membrane-proximal region of type I receptors are able to modulate the amplitude of signal transducer and activator of transcription 3 (STAT3) signaling in cells. This unexpected finding has implications for the prognosis of heritable cancer. ...[more]
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