Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants.

ABSTRACT: In cancer biology, somatic mutations in the extracellular (ligand binding) and cytosolic (functional/catalytic) domains are pursued with great interest. However, in our recent publication we report that germline mutations in the membrane-proximal region of type I receptors are able to modulate the amplitude of signal transducer and activator of transcription 3 (STAT3) signaling in cells. This unexpected finding has implications for the prognosis of heritable cancer.

SUBMITTER: Ulaganathan VK 

PROVIDER: S-EPMC4909399 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature