Ontology highlight
ABSTRACT:
SUBMITTER: Bain CC
PROVIDER: S-EPMC4910019 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nature communications 20160613
Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the composition, developmental origin and mechanisms governing the maintenance of this compartment are controversial. Here we show resident F4/80(hi)GATA6(+) macrophages are long-lived, undergo non-stochastic self-renewal and retain cells of embryonic origin for at least 4 months in mice. However, Ly6C(+) monocytes constitutively enter the peritoneal cavity in a CCR2-dependent manner, where they mature int ...[more]