Unknown

Dataset Information

0

Thyroglobulin fluctuations in patients with iodine-refractory differentiated thyroid carcinoma on lenvatinib treatment - initial experience.


ABSTRACT: Tyrosine kinase inhibitors (TKI) have shown clinical effectiveness in iodine-refractory differentiated thyroid cancer (DTC). The corresponding role of serum thyroglobulin (Tg) in iodine-refractory DTC has not been investigated yet. 9 patients (3 female, 61 ± 8y) with progressive iodine-refractory DTC starting on lenvatinib were considered. Tumor restaging was performed every 2-3 months including contrast-enhanced computed tomography (CT, RECIST 1.1). Serum Tg was measured and compared to imaging findings. After treatment initiation, serum Tg levels dropped in all patients with a median reduction of 86.2%. During long-term follow-up (median, 25.2 months), fluctuations in Tg could be observed in 8/9 subjects. According to RECIST, 6/9 subjects achieved a partial response or stable disease with the remaining 3/9 experiencing progressive disease (2/3 with Tg levels rising above baseline). All of the patients with disease progression presented with a preceding continuous rise in serum Tg, whereas tumor marker oscillations in the subjects with controlled disease were only intermittent. Initiation of lenvatinib in iodine-refractory DTC patients is associated with a significant reduction in serum Tg levels as a marker of treatment response. In the course of treatment, transient Tg oscillations are a frequent phenomenon that may not necessarily reflect morphologic tumor progression.

SUBMITTER: Werner RA 

PROVIDER: S-EPMC4910099 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6276762 | biostudies-other
| S-EPMC7482116 | biostudies-literature
| S-EPMC4206652 | biostudies-literature
| S-EPMC5393009 | biostudies-literature
| S-EPMC5509138 | biostudies-literature
| S-EPMC4319630 | biostudies-literature
| S-EPMC10636672 | biostudies-literature
| S-EPMC9641791 | biostudies-literature
| S-EPMC7788563 | biostudies-literature
| S-EPMC9142801 | biostudies-literature