Ontology highlight
ABSTRACT:
SUBMITTER: Chen CC
PROVIDER: S-EPMC4910953 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Chen Chun-Chieh CC Xing Li L Stark Marie M Ou Tingwei T Holla Prasida P Xiao Kai K Kamita Shizuo G SG Hammock Bruce D BD Lam Kit K Cheng R Holland RH
Nanomedicine (London, England) 20160120 4
<h4>Aim</h4>To design a theranostic capsule using the virus-like nanoparticle of the hepatitis E virus modified to display breast cancer cell targeting functional group (LXY30).<h4>Methods</h4>Five surface-exposed residues were mutated to cysteine to allow conjugation to maleimide-linked chemical groups via thiol-selective linkages. Engineered virus-like nanoparticles were then covalently conjugated to a breast cancer recognized ligand, LXY30 and an amine-coupled near-infrared fluorescence dye.< ...[more]