Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Antidepressants have been empirically used in the treatment of functional dyspepsia (FD). However, results from recent clinical trials investigating their efficacy are conflicting. The aim of this study is to evaluate the efficacy of antidepressants in the management of FD in adults.

Methods

Databases of MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and BIOSIS Previews were searched for all randomized controlled trials (RCT) investigating efficacy of antidepressants in the management of FD in adult patients. Data of overall symptom unimproved and adverse events were compared between the antidepressants and placebo group.

Results

The search strategy identified 432 citations. Of those, eight RCTs met the inclusion criteria and were inclu

SUBMITTER: Lu Y 

PROVIDER: S-EPMC4911162 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature