Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection.
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ABSTRACT:
SUBMITTER: Price JC
PROVIDER: S-EPMC4911239 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection.
Price Jennifer C JC Seaberg Eric C EC Phair John P JP Witt Mallory D MD Koletar Susan L SL Thio Chloe L CL
Journal of acquired immune deficiency syndromes (1999) 20160701 3
To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV ...[more]
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