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Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection.

ABSTRACT: To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV-monoinfected and 22% for coinfected men. Decreases in APRI were dependent on HIV suppression. This protective effect of HAART decreased after 2 years, particularly in the HIV-monoinfected men.

SUBMITTER: Price JC 

PROVIDER: S-EPMC4911239 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Brief Report: Highly Active Antiretroviral Therapy Mitigates Liver Disease in HIV Infection.

Price Jennifer C JC   Seaberg Eric C EC   Phair John P JP   Witt Mallory D MD   Koletar Susan L SL   Thio Chloe L CL  

Journal of acquired immune deficiency syndromes (1999) 20160701 3

To determine the impact of highly active antiretroviral therapy (HAART) on liver disease, we analyzed changes in the aspartate aminotransferase to platelet ratio index (APRI) pre- and post-HAART initiation among 441 HIV-monoinfected and 53 HIV-viral hepatitis-coinfected men. Before HAART, APRI increased 17% and 34% among the HIV-monoinfected and coinfected men, respectively. With HAART initiation, APRI decreased significantly in men who achieved HIV RNA of <500 copies per milliliter: 16% for HIV  ...[more]

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