Progress and prospects for L2-based human papillomavirus vaccines.
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ABSTRACT:
SUBMITTER: Jiang RT
PROVIDER: S-EPMC4911254 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Progress and prospects for L2-based human papillomavirus vaccines.
Jiang Rosie T RT Schellenbacher Christina C Chackerian Bryce B Roden Richard B S RB
Expert review of vaccines 20160310 7
Human papillomavirus (HPV) is a worldwide public health problem, particularly in resource-limited countries. Fifteen high-risk genital HPV types are sexually transmitted and cause 5% of all cancers worldwide, primarily cervical, anogenital and oropharyngeal carcinomas. Skin HPV types are generally associated with benign disease, but a subset is linked to non-melanoma skin cancer. Licensed HPV vaccines based on virus-like particles (VLPs) derived from L1 major capsid antigen of key high risk HPVs ...[more]
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