Ontology highlight
ABSTRACT:
SUBMITTER: Guerrant W
PROVIDER: S-EPMC4911274 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cancer research 20160523 12
The Hippo-YAP pathway has emerged as a major driver of tumorigenesis in many human cancers. YAP is a transcriptional coactivator and while details of YAP regulation are quickly emerging, it remains unknown what downstream targets are critical for the oncogenic functions of YAP. To determine the mechanisms involved and to identify disease-relevant targets, we examined the role of YAP in neurofibromatosis type 2 (NF2) using cell and animal models. We found that YAP function is required for NF2-nul ...[more]