Ontology highlight
ABSTRACT:
SUBMITTER: Kuperman Y
PROVIDER: S-EPMC4911344 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cell metabolism 20160519 6
Signaling by the corticotropin-releasing factor receptor type 1 (CRFR1) plays an important role in mediating the autonomic response to stressful challenges. Multiple hypothalamic nuclei regulate sympathetic outflow. Although CRFR1 is highly expressed in the arcuate nucleus (Arc) of the hypothalamus, the identity of these neurons and the role of CRFR1 here are presently unknown. Our studies show that nearly half of Arc-CRFR1 neurons coexpress agouti-related peptide (AgRP), half of which originate ...[more]