Ontology highlight
ABSTRACT:
SUBMITTER: Porter SN
PROVIDER: S-EPMC4911494 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Porter Shaina N SN Cluster Andrew S AS Signer Robert A J RAJ Voigtmann Jenna J Monlish Darlene A DA Schuettpelz Laura G LG Magee Jeffrey A JA
Stem cell reports 20160512 6
Pten negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway and is required to maintain quiescent adult hematopoietic stem cells (HSCs). Pten has been proposed to regulate HSCs cell autonomously and non-cell autonomously, but the relative importance of each mechanism has not been directly tested. Furthermore, the cytokines that activate the PI3K pathway upstream of Pten are not well defined. We sought to clarify whether Pten cell autonomously or non-cell autonomously regulates HSC ...[more]