Ontology highlight
ABSTRACT:
SUBMITTER: Kuruvilla JG
PROVIDER: S-EPMC4911500 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Stem cell reports 20160526 6
In response to ionizing radiation-induced injury, the normally quiescent intestinal stem cells marked by BMI1 participate in the regenerative response. Previously, we established a protective role for Krüppel-like factor 4 (KLF4) in the intestinal epithelium where it reduces senescence, apoptosis, and crypt atrophy following γ-radiation-induced gut injury. We also described a pro-proliferative function for KLF4 during the regenerative phase post irradiation. In the current study, using a mouse m ...[more]