Ontology highlight
ABSTRACT:
SUBMITTER: Marzesco AM
PROVIDER: S-EPMC4911570 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Marzesco Anne-Marie AM Flötenmeyer Matthias M Bühler Anika A Obermüller Ulrike U Staufenbiel Matthias M Jucker Mathias M Baumann Frank F
Scientific reports 20160617
An early event in Alzheimer's disease (AD) pathogenesis is the formation of extracellular aggregates of amyloid-β peptide (Aβ), thought to be initiated by a prion-like seeding mechanism. However, the molecular nature and location of the Aβ seeds remain rather elusive. Active Aβ seeds are found in crude homogenates of amyloid-laden brains and in the soluble fraction thereof. To analyze the seeding activity of the pellet fraction, we have either separated or directly immunoisolated membranes from ...[more]