Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.
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ABSTRACT:
SUBMITTER: Mitchell SJ
PROVIDER: S-EPMC4911707 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.
Mitchell Sarah J SJ Madrigal-Matute Julio J Scheibye-Knudsen Morten M Fang Evandro E Aon Miguel M González-Reyes José A JA Cortassa Sonia S Kaushik Susmita S Gonzalez-Freire Marta M Patel Bindi B Wahl Devin D Ali Ahmed A Calvo-Rubio Miguel M Burón María I MI Guiterrez Vincent V Ward Theresa M TM Palacios Hector H HH Cai Huan H Frederick David W DW Hine Christopher C Broeskamp Filomena F Habering Lukas L Dawson John J Beasley T Mark TM Wan Junxiang J Ikeno Yuji Y Hubbard Gene G Becker Kevin G KG Zhang Yongqing Y Bohr Vilhelm A VA Longo Dan L DL Navas Placido P Ferrucci Luigi L Sinclair David A DA Cohen Pinchas P Egan Josephine M JM Mitchell James R JR Baur Joseph A JA Allison David B DB Anson R Michael RM Villalba José M JM Madeo Frank F Cuervo Ana Maria AM Pearson Kevin J KJ Ingram Donald K DK Bernier Michel M de Cabo Rafael R
Cell metabolism 20160601 6
Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigated the role of sex, strain, and level of CR on health and survival in mice. CR did not always correlate with lifespan extension, although it consistently improved health across strains and sexes. Transcriptional and metabolomics changes driven by CR in liver indicated anaplerotic filling of the Krebs cycle togeth ...[more]
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