Ontology highlight
ABSTRACT:
SUBMITTER: Mende M
PROVIDER: S-EPMC4912012 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Mende Michael M Fletcher Emily V EV Belluardo Josephine L JL Pierce Joseph P JP Bommareddy Praveen K PK Weinrich Jarret A JA Kabir Zeeba D ZD Schierberl Kathryn C KC Pagiazitis John G JG Mendelsohn Alana I AI Francesconi Anna A Edwards Robert H RH Milner Teresa A TA Rajadhyaksha Anjali M AM van Roessel Peter J PJ Mentis George Z GZ Kaltschmidt Julia A JA
Neuron 20160602 6
Circuit function in the CNS relies on the balanced interplay of excitatory and inhibitory synaptic signaling. How neuronal activity influences synaptic differentiation to maintain such balance remains unclear. In the mouse spinal cord, a population of GABAergic interneurons, GABApre, forms synapses with the terminals of proprioceptive sensory neurons and controls information transfer at sensory-motor connections through presynaptic inhibition. We show that reducing sensory glutamate release resu ...[more]