Ontology highlight
ABSTRACT:
SUBMITTER: Mokhtari S
PROVIDER: S-EPMC4912311 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Mokhtari Saloomeh S Colletti Evan J EJ Atala Anthony A Zanjani Esmail D ED Porada Christopher D CD Almeida-Porada Graça G
Stem cell reports 20160601 6
In utero hematopoietic stem/progenitor cell transplantation (IUHSCT) has only been fully successful in the treatment of congenital immunodeficiency diseases. Using sheep as a large animal model of IUHSCT, we demonstrate that administration of CD146(+)CXCL12(+)VEGFR2(+) or CD146(+)CXCL12(+)VEGFR2(-) cells prior to, or in combination with, hematopoietic stem/progenitor cells (HSC), results in robust CXCL12 production within the fetal marrow environment, and significantly increases the levels of he ...[more]