Ontology highlight
ABSTRACT:
SUBMITTER: Davis RJ
PROVIDER: S-EPMC4912416 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Oral oncology 20160520
A significant subset of head and neck cancers display a T-cell inflamed phenotype, suggesting that patients with these tumors should respond to therapeutic approaches aimed at strengthening anti-tumor immune responses. A major barrier to the development of an effective anti-tumor immune response, at baseline or in response to immunotherapy, is the development of an immunosuppressive tumor microenvironment. Several well described mechanisms of effector immune cell suppression in the head and neck ...[more]