Ontology highlight
ABSTRACT:
SUBMITTER: Song NJ
PROVIDER: S-EPMC4912433 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Song No-Joon NJ Choi Seri S Rajbhandari Prashant P Chang Seo-Hyuk SH Kim Suji S Vergnes Laurent L Kwon So-Mi SM Yoon Jung-Hoon JH Lee Sukchan S Ku Jin-Mo JM Lee Jeong-Soo JS Reue Karen K Koo Seung-Hoi SH Tontonoz Peter P Park Kye Won KW
Nature chemical biology 20160509 7
Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose ...[more]