Ontology highlight
ABSTRACT:
SUBMITTER: Ross W
PROVIDER: S-EPMC4912440 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Ross Wilma W Sanchez-Vazquez Patricia P Chen Albert Y AY Lee Jeong-Hyun JH Burgos Hector L HL Gourse Richard L RL
Molecular cell 20160526 6
Throughout the bacterial domain, the alarmone ppGpp dramatically reprograms transcription following nutrient limitation. This "stringent response" is critical for survival and antibiotic tolerance and is a model for transcriptional regulation by small ligands. We report that ppGpp binds to two distinct sites 60 Å apart on E. coli RNA polymerase (RNAP), one characterized previously (site 1) and a second identified here at an interface of RNAP and the transcription factor DksA (site 2). The locati ...[more]