Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Diaz C
PROVIDER: S-EPMC4912623 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Gomez-Diaz Carolina C Bargeton Benoîte B Abuin Liliane L Bukar Natalia N Reina Jaime H JH Bartoi Tudor T Graf Marion M Ong Huy H Ulbrich Maximilian H MH Masson Jean-Francois JF Benton Richard R
Nature communications 20160615
CD36 transmembrane proteins have diverse roles in lipid uptake, cell adhesion and pathogen sensing. Despite numerous in vitro studies, how they act in native cellular contexts is poorly understood. A Drosophila CD36 homologue, sensory neuron membrane protein 1 (SNMP1), was previously shown to facilitate detection of lipid-derived pheromones by their cognate receptors in olfactory cilia. Here we investigate how SNMP1 functions in vivo. Structure-activity dissection demonstrates that SNMP1's ectod ...[more]