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Effects of L-carnitine supplementation on lipid profiles in patients with coronary artery disease.


ABSTRACT: L-carnitine (LC) plays an important physiologic role in lipid metabolism. To date, no clinical study has been performed to examine the effect of LC supplementation on the lipid status of coronary artery disease (CAD) patients. The aim of this study was to investigate the lipid lowering effects of LC supplementation (1000 mg/d) in CAD patients.CAD patients were identified by cardiac catheterization as having at least 50 % stenosis of one major coronary artery. Forty-seven subjects were recruited and randomly assigned to the placebo (n?=?24) and to the LC (n?=?23) groups. The intervention was administered for 12 weeks. The levels of LC, lipid profiles, and antioxidant enzyme activity (superoxide dismutase, SOD) were measured.The subjects in the LC group had significantly higher SOD activity (20.7?±?4.2 versus 13.1?±?2.9 U/mg of protein, P?

SUBMITTER: Lee BJ 

PROVIDER: S-EPMC4912751 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Effects of L-carnitine supplementation on lipid profiles in patients with coronary artery disease.

Lee Bor-Jen BJ   Lin Jun-Shuo JS   Lin Yi-Chin YC   Lin Ping-Ting PT  

Lipids in health and disease 20160617


<h4>Background</h4>L-carnitine (LC) plays an important physiologic role in lipid metabolism. To date, no clinical study has been performed to examine the effect of LC supplementation on the lipid status of coronary artery disease (CAD) patients. The aim of this study was to investigate the lipid lowering effects of LC supplementation (1000 mg/d) in CAD patients.<h4>Methods</h4>CAD patients were identified by cardiac catheterization as having at least 50 % stenosis of one major coronary artery. F  ...[more]

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