Systematic review: third-line susceptibility-guided treatment for Helicobacter pylori infection.

ABSTRACT:

Background

Susceptibility-guided therapies (SGTs) have been proposed as preferable to empirical rescue treatments after two treatment failures. The aim of this study was to perform a systematic review and meta-analysis evaluating the effectiveness and efficacy of SGT as third-line therapy.

Methods

A systematic search was performed in multiple databases. Studies reporting cure rates of Helicobacter pylori with SGT in third-line therapy were selected. A qualitative analysis describing the current evidence and a pooled mean analysis summarizing the cure rates of SGT in third-line therapy was performed.

Results

No randomized controlled trials or comparative studies were found. Four observational studies reported cure rates with SGT in third-line treatment, and three studi

SUBMITTER: Puig I 

PROVIDER: S-EPMC4913327 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature