Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4914265 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zhang Yuan Y Liu Tian T Chen Yu Y Dong Zilong Z Zhang Jinxue J Sun Yizheng Y Jin Boquan B Gao Feng F Guo Shuzhong S Zhuang Ran R
Oncotarget 20160301 11
CD226 is a co-stimulatory adhesion molecule found on immune and endothelial cells. Here, we evaluated a possible role for CD226 in inhibiting glucose uptake in isolated human umbilical vein endothelial cells (HUVECs) and in wild-type (WT) and CD226 knockout (KO) mice with high-fat diet (HFD)-induced type 2 diabetes (T2DM). CD226 expression increased under hyperglycemic conditions in the presence of TNF-α. Furthermore, CD226 knockdown improved glucose uptake in endothelial cells, and CD226 KO mic ...[more]