Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava P
PROVIDER: S-EPMC4914325 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Srivastava Pragya P Paluch Benjamin E BE Matsuzaki Junko J James Smitha R SR Collamat-Lai Golda G Blagitko-Dorfs Nadja N Ford Laurie Ann LA Naqash Rafeh R Lübbert Michael M Karpf Adam R AR Nemeth Michael J MJ Griffiths Elizabeth A EA
Oncotarget 20160301 11
Cancer testis antigens (CTAs) are promising cancer associated antigens in solid tumors, but in acute myeloid leukemia, dense promoter methylation silences their expression. Leukemia cell lines exposed to HMAs induce expression of CTAs. We hypothesized that AML patients treated with standard of care decitabine (20mg/m2 per day for 10 days) would demonstrate induced expression of CTAs. Peripheral blood blasts serially isolated from AML patients treated with decitabine were evaluated for CTA gene e ...[more]