Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy.
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ABSTRACT:
SUBMITTER: Viallard C
PROVIDER: S-EPMC4914332 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy.
Viallard Claire C Chezal Jean-Michel JM Mishellany Florence F Ranchon-Cole Isabelle I Pereira Bruno B Herbette Aurélie A Besse Sophie S Boudhraa Zied Z Jacquemot Nathalie N Cayre Anne A Miot-Noirault Elisabeth E Sun Jian-Sheng JS Dutreix Marie M Degoul Françoise F
Oncotarget 20160301 11
Radiolabelled melanin ligands offer an interesting strategy for the treatment of disseminated pigmented melanoma. One of these molecules, ICF01012 labelled with iodine 131, induced a significant slowing of melanoma growth. Here, we have explored the combination of [131I]ICF01012 with coDbait, a DNA repair inhibitor, to overcome melanoma radioresistance and increase targeted radionuclide therapy (TRT) efficacy. In human SK-Mel 3 melanoma xenograft, the addition of coDbait had a synergistic effect ...[more]
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