Ontology highlight
ABSTRACT:
SUBMITTER: Viallard C
PROVIDER: S-EPMC4914332 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Oncotarget 20160301 11
Radiolabelled melanin ligands offer an interesting strategy for the treatment of disseminated pigmented melanoma. One of these molecules, ICF01012 labelled with iodine 131, induced a significant slowing of melanoma growth. Here, we have explored the combination of [131I]ICF01012 with coDbait, a DNA repair inhibitor, to overcome melanoma radioresistance and increase targeted radionuclide therapy (TRT) efficacy. In human SK-Mel 3 melanoma xenograft, the addition of coDbait had a synergistic effect ...[more]