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Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA).


ABSTRACT: AIMS:To test the hypothesis that soluble cellular adhesion molecules would be positively and independently associated with risk of diabetes. METHODS:Soluble levels of six cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1, E-cadherin, L-selectin and P-selectin) were measured in participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort study. Participants were then followed for up to 10 years to ascertain incident diabetes. RESULTS:Sample sizes ranged from 826 to 2185. After adjusting for age, sex, race/ethnicity, BMI and fasting glucose or HbA1c , four cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1 and E-cadherin) were positively associated with incident diabetes and there was a statistically significant trend across quartiles. Comparing the incidence of diabetes in the highest and lowest quartiles of each cellular adhesion molecule, the magnitude of association was largest for E-selectin (hazard ratio 2.49; 95% CI 1.26-4.93) and ICAM-1 (hazard ratio 1.76; 95% CI 1.22-2.55) in fully adjusted models. Tests of effect modification by racial/ethnic group and sex were not statistically significant for any of the cellular adhesion molecules (P > 0.05). CONCLUSIONS:The finding of significant associations between multiple cellular adhesion molecules and incident diabetes may lend further support to the hypothesis that microvascular endothelial dysfunction contributes to risk of diabetes.

SUBMITTER: Pankow JS 

PROVIDER: S-EPMC4914403 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA).

Pankow J S JS   Decker P A PA   Berardi C C   Hanson N Q NQ   Sale M M   Tang W W   Kanaya A M AM   Larson N B NB   Tsai M Y MY   Wassel C L CL   Bielinski S J SJ  

Diabetic medicine : a journal of the British Diabetic Association 20160325 7


<h4>Aims</h4>To test the hypothesis that soluble cellular adhesion molecules would be positively and independently associated with risk of diabetes.<h4>Methods</h4>Soluble levels of six cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1, E-cadherin, L-selectin and P-selectin) were measured in participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort study. Participants were then followed for up to 10 years to ascertain incident diabetes.<h4>Results</h4>Sample sizes ran  ...[more]

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