Ontology highlight
ABSTRACT:
SUBMITTER: Ito-Horiyama T
PROVIDER: S-EPMC4914688 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Ito-Horiyama Tsukasa T Ishii Yoshikazu Y Ito Akinobu A Sato Takafumi T Nakamura Rio R Fukuhara Norio N Tsuji Masakatsu M Yamano Yoshinori Y Yamaguchi Keizo K Tateda Kazuhiro K
Antimicrobial agents and chemotherapy 20160620 7
To better understand the antibacterial activity of S-649266 against carbapenemase producers, its stability against clinically relevant carbapenemases was investigated. The catalytic efficiencies (kcat/Km) of IMP-1, VIM-2, and L1 for S-649266 were 0.0048, 0.0050, and 0.024 μM(-1) s(-1), respectively, which were more than 260-fold lower than that for meropenem. Only slight hydrolysis of S-649266 against KPC-3 was observed. NDM-1 hydrolyzed meropenem 3-fold faster than S-649266 at 200 μM. ...[more]