Ontology highlight
ABSTRACT:
SUBMITTER: Farooq F
PROVIDER: S-EPMC4914957 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20160621
The most recent Zaire Ebolavirus (ZEBOV) outbreak was the largest and most widespread in recorded history, emphasizing the need for an effective vaccine. Here, we analyzed human cellular immune responses induced by a single dose of the rVSV-ZEBOV vaccine candidate, which showed significant protective efficacy in endemic populations in Guinea. This is the first in-depth characterization of ZEBOV-GP specific, circulating follicular T cells (cTfh). Since antibody titers correlated with protection i ...[more]