Ontology highlight
ABSTRACT:
SUBMITTER: Muroyama A
PROVIDER: S-EPMC4915192 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Muroyama Andrew A Seldin Lindsey L Lechler Terry T
The Journal of cell biology 20160613 6
Differentiation induces the formation of noncentrosomal microtubule arrays in diverse tissues. The formation of these arrays requires loss of microtubule-organizing activity (MTOC) at the centrosome, but the mechanisms regulating this transition remain largely unexplored. Here, we use the robust loss of centrosomal MTOC activity in the epidermis to identify two pools of γ-tubulin that are biochemically and functionally distinct and differentially regulated. Nucleation-competent CDK5RAP2-γ-tubuli ...[more]