Ontology highlight
ABSTRACT:
SUBMITTER: Imamura T
PROVIDER: S-EPMC4916297 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Imamura T T Kiyokawa N N Kato M M Imai C C Okamoto Y Y Yano M M Ohki K K Yamashita Y Y Kodama Y Y Saito A A Mori M M Ishimaru S S Deguchi T T Hashii Y Y Shimomura Y Y Hori T T Kato K K Goto H H Ogawa C C Koh K K Taki T T Manabe A A Sato A A Kikuta A A Adachi S S Horibe K K Ohara A A Watanabe A A Kawano Y Y Ishii E E Shimada H H
Blood cancer journal 20160513
Recent studies revealed that a substantial proportion of patients with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harbor fusions involving tyrosine kinase and cytokine receptors, such as ABL1, PDGFRB, JAK2 and CRLF2, which are targeted by tyrosine kinase inhibitors (TKIs). In the present study, transcriptome analysis or multiplex reverse transcriptase-PCR analysis of 373 BCP-ALL patients without recurrent genetic abnormalities identified 29 patients with kinase fusions. Cl ...[more]