Ontology highlight
ABSTRACT:
SUBMITTER: Skarpengland T
PROVIDER: S-EPMC4916448 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Skarpengland Tonje T Holm Sverre S Scheffler Katja K Gregersen Ida I Dahl Tuva B TB Suganthan Rajikala R Segers Filip M FM Østlie Ingunn I Otten Jeroen J T JJ Luna Luisa L Ketelhuth Daniel F J DF Lundberg Anna M AM Neurauter Christine G CG Hildrestrand Gunn G Skjelland Mona M Bjørndal Bodil B Svardal Asbjørn M AM Iversen Per O PO Hedin Ulf U Nygård Ståle S Olstad Ole K OK Krohg-Sørensen Kirsten K Slupphaug Geir G Eide Lars L Kuśnierczyk Anna A Folkersen Lasse L Ueland Thor T Berge Rolf K RK Hansson Göran K GK Biessen Erik A L EA Halvorsen Bente B Bjørås Magnar M Aukrust Pål P
Scientific reports 20160622
Increasing evidence suggests that oxidative DNA damage accumulates in atherosclerosis. Recently, we showed that a genetic variant in the human DNA repair enzyme NEIL3 was associated with increased risk of myocardial infarction. Here, we explored the role of Neil3/NEIL3 in atherogenesis by both clinical and experimental approaches. Human carotid plaques revealed increased NEIL3 mRNA expression which significantly correlated with mRNA levels of the macrophage marker CD68. Apoe(-/-)Neil3(-/-) mice ...[more]