Ontology highlight
ABSTRACT:
SUBMITTER: Vernooij RR
PROVIDER: S-EPMC4916484 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Vernooij Robbin R RR Joshi Tanmaya T Shaili Evyenia E Kubeil Manja M Appadoo Dominique R T DR Izgorodina Ekaterina I EI Graham Bim B Sadler Peter J PJ Wood Bayden R BR Spiccia Leone L
Inorganic chemistry 20160603 12
We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR ...[more]