Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.
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ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC4916787 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.
Zhang Cheng C Lee Sunjae S Mardinoglu Adil A Hua Qiang Q
Frontiers in physiology 20160502
Co-expressed genes often share similar functions, and gene co-expression networks have been widely used in studying the functionality of gene modules. Previous analysis indicated that genes are more likely to be co-expressed if they are either regulated by the same transcription factors, forming protein complexes or sharing similar topological properties in protein-protein interaction networks. Here, we reconstructed transcriptional regulatory and protein-protein networks for Saccharomyces cerev ...[more]
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