Ontology highlight
ABSTRACT:
SUBMITTER: Drilon A
PROVIDER: S-EPMC4917003 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Drilon Alexander A Wang Lu L Arcila Maria E ME Balasubramanian Sohail S Greenbowe Joel R JR Ross Jeffrey S JS Stephens Phil P Lipson Doron D Miller Vincent A VA Kris Mark G MG Ladanyi Marc M Rizvi Naiyer A NA
Clinical cancer research : an official journal of the American Association for Cancer Research 20150107 16
<h4>Purpose</h4>Broad, hybrid capture-based next-generation sequencing (NGS), as a clinical test, uses less tissue to identify more clinically relevant genomic alterations compared with profiling with multiple non-NGS tests. We set out to determine the frequency of such genomic alterations via this approach in tumors in which previous extensive non-NGS testing had not yielded a targetable driver alteration.<h4>Experimental design</h4>We enrolled patients with lung adenocarcinoma with a ≤ 15 pack ...[more]