Unknown

Dataset Information

0

Traditional and non-traditional risk factors for incident peripheral arterial disease among patients with chronic kidney disease.


ABSTRACT:

Background

The risk of peripheral arterial disease (PAD) is higher in patients with chronic kidney disease (CKD) compared with those without. However, reasons for this increased risk are not fully understood.

Methods

We studied risk factors for incident PAD among 3169 participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Patients with CKD aged 21-74 years were recruited between 2003 and 2008 and followed for a median of 6.3 years. Incident PAD was defined as a new onset ankle-brachial index (ABI) of <0.9 or confirmed clinical PAD.

Results

In a multivariate-adjusted model, older age, female sex, non-Hispanic Black, current smoking, diabetes, higher pulse pressure, lower high-density lipoprotein cholesterol, higher low-density lipoprotein cholesterol, and lower estimated glomerular filtration rate were significantly associated with the increased risk of incident PAD. After adjustment for these traditional risk factors as well as use of medications and CRIC Study clinic sites, the following baseline novel risk factors were significantly associated with risk of incident PAD [hazard ratio and 95% confidence interval (CI) for a one standard deviation (SD) higher level]: log[C-reactive protein (CRP)] (1.16, 1.06-1.25, P < 0.001), white blood cell count (1.09, 1.01-1.18, P = 0.03), fibrinogen (1.15, 1.06-1.26, P = 0.002), log(myeloperoxidase) (1.12, 1.03-1.23, P = 0.01), uric acid (0.88, 0.80-0.97, P = 0.01), glycated hemoglobin (1.16, 1.05-1.27, P = 0.003), log(homeostatic model assessment-insulin resistance) (1.21, 1.10-1.32, P < 0.001) and alkaline phosphatase (1.15, 1.07-1.24, P < 0.001).

Conclusions

Among patients with CKD, inflammation, prothrombotic state, oxidative stress, glycated hemoglobin, insulin resistance and alkaline phosphatase are associated with an increased risk of PAD, independent of traditional risk factors.

SUBMITTER: Chen J 

PROVIDER: S-EPMC4917062 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Traditional and non-traditional risk factors for incident peripheral arterial disease among patients with chronic kidney disease.

Chen Jing J   Mohler Emile R ER   Xie Dawei D   Shlipak Michael M   Townsend Raymond R RR   Appel Lawrence J LJ   Ojo Akinlolu A   Schreiber Martin M   Nessel Lisa L   Zhang Xiaoming X   Raj Dominic D   Strauss Louise L   Lora Claudia M CM   Rahman Mahboob M   Hamm L Lee LL   He Jiang J  

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20151218 7


<h4>Background</h4>The risk of peripheral arterial disease (PAD) is higher in patients with chronic kidney disease (CKD) compared with those without. However, reasons for this increased risk are not fully understood.<h4>Methods</h4>We studied risk factors for incident PAD among 3169 participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Patients with CKD aged 21-74 years were recruited between 2003 and 2008 and followed for a median of 6.3 years. Incident PAD was defined as a new o  ...[more]

Similar Datasets

| S-EPMC10272583 | biostudies-literature
| S-EPMC4190067 | biostudies-literature
| S-EPMC6306329 | biostudies-literature
2022-11-29 | GSE184420 | GEO
| S-EPMC6881518 | biostudies-literature
| S-EPMC6865298 | biostudies-literature
| S-EPMC5649254 | biostudies-literature
| S-EPMC3953643 | biostudies-literature
| S-EPMC6617052 | biostudies-literature
| S-EPMC3606168 | biostudies-literature