Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.
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ABSTRACT:
SUBMITTER: Wongrakpanich A
PROVIDER: S-EPMC4917228 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.
Wongrakpanich Amaraporn A Mudunkotuwa Imali A IA Geary Sean M SM Morris Angie S AS Mapuskar Kranti A KA Spitz Douglas R DR Grassian Vicki H VH Salem Aliasger K AK
Environmental science. Nano 20160224 2
The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the <i>in vitro</i> cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, po ...[more]
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