Ontology highlight
ABSTRACT:
SUBMITTER: Hachiya Y
PROVIDER: S-EPMC4917238 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hachiya Yuki Y Kawasaki Aya A Oka Shomi S Kondo Yuya Y Ito Satoshi S Matsumoto Isao I Kusaoi Makio M Amano Hirofumi H Suda Akiko A Setoguchi Keigo K Nagai Tatsuo T Shimada Kota K Sugii Shoji S Okamoto Akira A Chiba Noriyuki N Suematsu Eiichi E Ohno Shigeru S Katayama Masao M Kono Hajime H Hirohata Shunsei S Takasaki Yoshinari Y Hashimoto Hiroshi H Sumida Takayuki T Nagaoka Shouhei S Tohma Shigeto S Furukawa Hiroshi H Tsuchiya Naoyuki N
PloS one 20160622 6
HLA-G plays a role in fetal-maternal tolerance as well as immunoregulation, and has been suggested to be involved in autoimmune diseases and cancers. HLA-G encodes two potentially functional polymorphisms in the 3' untranslated region, 14bp insertion/deletion (14bp indel, rs371194629) and a single nucleotide polymorphism rs1063320, previously reported to affect HLA-G expression level or splicing isoform and to be associated with susceptibility to systemic lupus erythematosus (SLE). However, the ...[more]