Ontology highlight
ABSTRACT:
SUBMITTER: Burns KE
PROVIDER: S-EPMC4917822 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Burns Kelly E KE McCleerey Tanner P TP Thévenin Damien D
Scientific reports 20160623
Positively charged antimicrobial peptides have become promising agents for the treatment of cancer by inducing apoptosis though their preferential binding and disruption of negatively charged membranes, such as the mitochondrial membrane. (KLAKLAK)2 is such a peptide but due to its polarity, it cannot cross the cellular membrane and therefore relies on the use of a delivery agent. For targeted delivery, previous studies have relied on cell penetrating peptides, nanoparticles or specific biomarke ...[more]